Ну чё - я опять говорил
Apr. 24th, 2020 03:52 am![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
techworkhttps://techwork.livejournal.com/853513.html
https://www.ft.com/content/0a4872d1-4cac-4040-846f-ce32daa09d99
Так что да - лекарств уже целая куча и реально работающих - но НЕ ЭТО .
Gilead antiviral drug remdesivir flops in first trial
Exclusive: Disappointing results revealed in draft documents published accidentally by WHO
Chinese trial showed remdesivir — developed by California-based Gilead Sciences — did not improve patients’ condition © AFP via Getty Images
Donato Paolo Mancini in London and Hannah Kuchler in New York yesterday
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Be the first to know about every new Coronavirus story
A potential antiviral drug for the coronavirus has flopped in its first randomised clinical trial, disappointing scientists and investors who had high hopes for remdesivir, according to draft documents published accidentally by the World Health Organization and seen by the Financial Times.
The Chinese trial showed remdesivir — developed by California-based Gilead Sciences — did not improve patients’ condition or reduce the pathogen’s presence in the bloodstream. Researchers studied 237 patients, giving the drug to 158 and comparing their progress with the remaining 79. The drug also showed significant side effects in some, which meant 18 patients were taken off it.
The WHO said the draft document, which is undergoing peer review, was published early in error. “In response to WHO asking for information and studies to be shared early, a draft document was provided by the authors to WHO and inadvertently posted on the website and taken down as soon as the mistake was noticed,” it said.
Gilead warned that the post included “inappropriate characterisations of the study”.
“Importantly, because this study was terminated early due to low enrolment, it was underpowered to enable statistically meaningful conclusions,” it said. “As such, the study results are inconclusive, though trends in the data suggest a potential benefit for remdesivir, particularly among patients treated early in disease.”
Gilead trading was briefly halted on the Nasdaq on Thursday after the shares fell sharply on the news of the results of the study, and ended the day down more than 4 per cent at about $77.78. The stock surged to a high of almost $84 last week on hopes for remdesivir, valuing the company at nearly $100bn.
Until now, evidence from the use of Gilead’s remdesivir on treating Covid-19 had relied on studies that did not meet the robust scientific standards of being randomised and having a control arm.
There are multiple ongoing Phase 3 studies that are designed to provide the additional data needed to determine the potential for remdesivir as a treatment for Covid-19. These studies will help inform whom to treat, when to treat and how long to treat with remdesivir. The studies are either fully enrolled for the primary analysis or on track to fully enrol in the near future.
Positive feedback from a clinical trial being conducted at the University of Chicago, leaked last week, buoyed the entire stock market as investors looked for any sign that the availability of a successful drug could help open up locked down economies.
“In this study of hospitalised adult patients with severe Covid-19 that was terminated prematurely, remdesivir was not associated with clinical or virological benefits,” the filing said.
The WHO collates current trials for possible Covid-19 interventions on a website titled “landscape analysis of candidate therapeutics for Covid-19.” A previous version of the website, which contained five pages and a column called “outcomes,” is no longer available. The new one only contains four pages and no “outcome” column.
The study was terminated early because of a lack of patients. It was conducted in China, which after a surge in cases earlier this year has seen a taper in the number of those affected.
Earlier this month, a study in the New England Journal of Medicine showed early positive results for remdesivir, with 68 per cent of patients improving on the drug. However, the study was not an official trial but rather the collation of data from patients who had been given the drug on a “compassionate use” basis — and was not compared to any control arm. The scientists behind the study and Gilead warned at the time that it was not conclusive.
There had been other positive signs too. Early impressions from a study showed rapid recoveries in almost all of the more than a hundred severely ill patients, when they were leaked to healthcare industry publication Stat news.
A recent US National Institutes of Health animal study also found the drug was effective at treating the disease in monkeys, when taken early in its progression.
Much larger randomised controlled trials are under way, comparing remdesivir with controls, which in Covid-19 usually means standard care for a respiratory illness, and to other drugs including the antimalarial hydroxychloroquine.
Gilead originally developed remdesivir as a treatment for Ebola, where it showed promise at stopping the virus from replicating in clinical trials, but it has never been approved.
https://www.ft.com/content/0a4872d1-4cac-4040-846f-ce32daa09d99
Так что да - лекарств уже целая куча и реально работающих - но НЕ ЭТО .
Gilead antiviral drug remdesivir flops in first trial
Exclusive: Disappointing results revealed in draft documents published accidentally by WHO
Chinese trial showed remdesivir — developed by California-based Gilead Sciences — did not improve patients’ condition © AFP via Getty Images
Donato Paolo Mancini in London and Hannah Kuchler in New York yesterday
Print this page
308
Be the first to know about every new Coronavirus story
A potential antiviral drug for the coronavirus has flopped in its first randomised clinical trial, disappointing scientists and investors who had high hopes for remdesivir, according to draft documents published accidentally by the World Health Organization and seen by the Financial Times.
The Chinese trial showed remdesivir — developed by California-based Gilead Sciences — did not improve patients’ condition or reduce the pathogen’s presence in the bloodstream. Researchers studied 237 patients, giving the drug to 158 and comparing their progress with the remaining 79. The drug also showed significant side effects in some, which meant 18 patients were taken off it.
The WHO said the draft document, which is undergoing peer review, was published early in error. “In response to WHO asking for information and studies to be shared early, a draft document was provided by the authors to WHO and inadvertently posted on the website and taken down as soon as the mistake was noticed,” it said.
Gilead warned that the post included “inappropriate characterisations of the study”.
“Importantly, because this study was terminated early due to low enrolment, it was underpowered to enable statistically meaningful conclusions,” it said. “As such, the study results are inconclusive, though trends in the data suggest a potential benefit for remdesivir, particularly among patients treated early in disease.”
Gilead trading was briefly halted on the Nasdaq on Thursday after the shares fell sharply on the news of the results of the study, and ended the day down more than 4 per cent at about $77.78. The stock surged to a high of almost $84 last week on hopes for remdesivir, valuing the company at nearly $100bn.
Until now, evidence from the use of Gilead’s remdesivir on treating Covid-19 had relied on studies that did not meet the robust scientific standards of being randomised and having a control arm.
There are multiple ongoing Phase 3 studies that are designed to provide the additional data needed to determine the potential for remdesivir as a treatment for Covid-19. These studies will help inform whom to treat, when to treat and how long to treat with remdesivir. The studies are either fully enrolled for the primary analysis or on track to fully enrol in the near future.
Positive feedback from a clinical trial being conducted at the University of Chicago, leaked last week, buoyed the entire stock market as investors looked for any sign that the availability of a successful drug could help open up locked down economies.
“In this study of hospitalised adult patients with severe Covid-19 that was terminated prematurely, remdesivir was not associated with clinical or virological benefits,” the filing said.
The WHO collates current trials for possible Covid-19 interventions on a website titled “landscape analysis of candidate therapeutics for Covid-19.” A previous version of the website, which contained five pages and a column called “outcomes,” is no longer available. The new one only contains four pages and no “outcome” column.
The study was terminated early because of a lack of patients. It was conducted in China, which after a surge in cases earlier this year has seen a taper in the number of those affected.
Earlier this month, a study in the New England Journal of Medicine showed early positive results for remdesivir, with 68 per cent of patients improving on the drug. However, the study was not an official trial but rather the collation of data from patients who had been given the drug on a “compassionate use” basis — and was not compared to any control arm. The scientists behind the study and Gilead warned at the time that it was not conclusive.
There had been other positive signs too. Early impressions from a study showed rapid recoveries in almost all of the more than a hundred severely ill patients, when they were leaked to healthcare industry publication Stat news.
A recent US National Institutes of Health animal study also found the drug was effective at treating the disease in monkeys, when taken early in its progression.
Much larger randomised controlled trials are under way, comparing remdesivir with controls, which in Covid-19 usually means standard care for a respiratory illness, and to other drugs including the antimalarial hydroxychloroquine.
Gilead originally developed remdesivir as a treatment for Ebola, where it showed promise at stopping the virus from replicating in clinical trials, but it has never been approved.
![[identity profile]](https://www.dreamwidth.org/img/silk/identity/openid.png){kind=small}
no subject
Date: 2020-04-24 04:23 am (UTC)no subject
Date: 2020-04-24 06:06 am (UTC)А так вообще по возможности в больницы сейчас лучше не обращаться - подозрительные диагнозирования именно у медперсонала пошли - которые очень подозрительны. Ибо например в районе 20 подозреваемых и 6 из них медики. Лажа полная.
Но ещё раз Лукашенко уже разобачил фальшивые тесты из РФ которые всегда положительные согласно проценту заданному Партией и Правительством.
no subject
Date: 2020-04-24 06:16 am (UTC)no subject
Date: 2020-04-24 06:28 am (UTC)Ну а тебя посадят под домашний арест если у неё положительно а у тебя нет.
no subject
Date: 2020-04-24 06:34 am (UTC)no subject
Date: 2020-04-24 08:17 am (UTC)Автор целый список приводил. Бери сухое или концентрат. Я вот пихтой дышал, аромомаслом=)
no subject
Date: 2020-04-24 05:11 pm (UTC)no subject
Date: 2020-04-24 07:00 am (UTC)no subject
Date: 2020-04-24 05:13 pm (UTC)no subject
Date: 2020-04-24 07:53 am (UTC)Зачастую, как раз проблема, сделать тест и попасть в госпиталь.
НО, тем кто остался лечиться дома, надевают "бубенчик" на нос:
"Пациенты с легкой формой коронавируса, давшие согласие на лечение в домашних условиях, должны отвечать на пуш-уведомления смартфона и делать селфи для подтверждения режима самоизоляции"..
no subject
Date: 2020-04-24 08:32 am (UTC)no subject
Date: 2020-04-24 05:17 pm (UTC)no subject
Date: 2020-04-24 05:14 pm (UTC)